Welcome to the Nature Products Discovery Tool Platform
AttB-find
AttB-find is a web tool to identify the attB integration sites in microbial genomes. It uses BLAST analysis to find potential attB sites based on sequence similarity and scoring thresholds.
RiPPs Analysis
Coming soon... Tools for analyzing Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) in genomic data.
Other Tools
Access additional bioinformatics tools and utilities for comprehensive genomic analysis and data
processing.
Coming soon...
Issues and Questions
Please submit any issues or questions that you may have.
Email: zhengjie.liu@sjtu.edu.cn
Cite our work
Please cite our work if you use this platform in your research:
Development of a versatile chassis for the efficient production of diverse type II
polyketides.
Zou Y, Wang R, Liu Z, Zou Y, Zeng S, Fang M, Chen H, Wang P, Xie C, Deng Z, Zhang F, Liu R, Liu
T. Nat Commun. 2025 Aug 8;16(1):7321. doi:
10.1038/s41467-025-62659-0.
References
Sequences in attB that affect the ability of phiC31 integrase to synapse and to activate
DNA cleavage.
Gupta M, Till R, Smith MC. Nucleic Acids Res. 2007;35:3407-19. doi: 10.1093/nar/gkm206.
New ΦBT1 site-specific integrative vectors with neutral phenotype in
Streptomyces.
Gonzalez-Quiñonez N, López-García MT, Yagüe P, Rioseras B, Pisciotta A,
Alduina R, Manteca Á. Appl Microbiol Biotechnol. 2016;100:2797-808. doi: 10.1007/s00253-015-7271-0.
aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular
recombinases in actinomycetes.
Li L, Wei K, Liu X, Wu Y, Zheng G, Chen S, Jiang W, Lu Y. Metab Eng. 2019;52:153-167.
doi: 10.1016/j.ymben.2018.12.001.
Systematic discovery of recombinases for efficient integration of large DNA sequences into
the human genome.
Durrant MG, Fanton A, Tycko J, Hinks M, Chandrasekaran SS, Perry NT, Schaepe J, Du PP, Lotfy P,
Bassik MC, Bintu L, Bhatt AS, Hsu PD. Nat Biotechnol. 2023;41:488-499. doi: 10.1038/s41587-022-01494-w.